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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MYLK
All Species:
12.42
Human Site:
Y846
Identified Species:
39.05
UniProt:
Q15746
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15746
NP_444253.3
1914
210774
Y846
D
G
G
G
S
D
R
Y
G
S
L
R
P
G
W
Chimpanzee
Pan troglodytes
XP_001168476
1914
210741
Y846
D
G
G
G
S
D
H
Y
G
S
L
R
P
G
W
Rhesus Macaque
Macaca mulatta
XP_001113525
1914
210379
Y846
D
G
G
G
S
D
R
Y
G
T
L
R
P
G
W
Dog
Lupus familis
XP_849008
1914
210137
Y843
D
G
G
G
G
D
C
Y
G
T
L
R
P
G
R
Cat
Felis silvestris
Mouse
Mus musculus
Q6PDN3
1941
212907
H834
A
H
G
D
G
D
R
H
G
T
L
R
P
C
W
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P11799
1906
210428
R860
Y
G
A
L
T
F
G
R
T
S
G
F
K
K
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001099152
899
100637
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787033
2753
301994
G1501
E
V
Y
P
D
D
A
G
I
Y
T
C
K
I
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
97.3
87.7
N.A.
84.3
N.A.
N.A.
N.A.
69
N.A.
33.9
N.A.
N.A.
N.A.
N.A.
26.6
Protein Similarity:
100
99.3
98.3
91.9
N.A.
89.4
N.A.
N.A.
N.A.
79.2
N.A.
40.5
N.A.
N.A.
N.A.
N.A.
40.7
P-Site Identity:
100
93.3
93.3
73.3
N.A.
53.3
N.A.
N.A.
N.A.
13.3
N.A.
0
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
93.3
100
80
N.A.
66.6
N.A.
N.A.
N.A.
20
N.A.
0
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
13
0
0
0
13
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
13
0
0
0
0
13
0
13
0
% C
% Asp:
50
0
0
13
13
75
0
0
0
0
0
0
0
0
0
% D
% Glu:
13
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
13
0
0
0
0
0
13
0
0
13
% F
% Gly:
0
63
63
50
25
0
13
13
63
0
13
0
0
50
0
% G
% His:
0
13
0
0
0
0
13
13
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
13
0
0
0
0
13
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
25
13
0
% K
% Leu:
0
0
0
13
0
0
0
0
0
0
63
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
13
0
0
0
0
0
0
0
0
63
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
38
13
0
0
0
63
0
0
13
% R
% Ser:
0
0
0
0
38
0
0
0
0
38
0
0
0
0
13
% S
% Thr:
0
0
0
0
13
0
0
0
13
38
13
0
0
0
0
% T
% Val:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
50
% W
% Tyr:
13
0
13
0
0
0
0
50
0
13
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _